‘Yes, that is certainly about ideal. I hunt for a Actual physical understanding of biological devices inside a bottom-up way. I feel you can distinguish 3 strains of research in my group at the moment. The primary fears chromosome structure: How would you receive a metre-long DNA polymer folded and organised in this type of microscopic cell? Now we have developed visualisation strategies that let us to check how, for example, SMC proteins loop DNA (video clip on Youtube) in an effort to Make up chromosomes.
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As being a individual, I provide the biblical assignment to investigate and use almost everything in generation for the benefit of my neighbour. I will not experience any conflict among religion and science. Quite the opposite, my religion stimulates me to complete science, to get open up-minded on the globe.’
Nanofabrication of electrodes with sub-5 nm spacing for transportation experiments on single molecules and steel clusters
2015, discovery that condensin is a remarkably versatile protein structure; and initially detection of DNA knots making use of nanopores
The coiled-coil in the human Rad50 DNA restore protein incorporates distinct segments of elevated adaptability
MATLAB codes for knowledge processing are available at . Julia codes useful for numerical simulation can be found at .
Atomic force microscopy ceesdekker displays that vaccinia topoisomerase IB generates filaments on DNA in a very cooperative fashion
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Right now, we also recognized that it should be feasible to make use of a single semiconducting carbon nanotube to make a transistor — and we set out to really make it. We stretched unique semiconducting nanotubes throughout metallic electrodes and utilised the underlying silicon substrate as being a gate electrode, establishing The essential 3-terminal format of a industry-influence transistor (Fig.
Example (four) of bending configurations in 3D simulations of DNA rods on nanopores. A percentage of the membrane is proven in grey, the rim of the pore is highlighted in pink, and also a 3D rendering on the motion of the DNA rod is exhibited.
Afterwards we spoke yet again briefly because Dekker felt that our discussion of his faith speedily grew to become purely philosophical, Whilst it also concretely aids him in his operate.
Visualization of unstained DNA nanostructures with advanced in-concentrate transmission electron microscopy strategies
Reliable-condition nanopores have established to get a amazingly functional probe for one-molecule Investigation of DNA. I'll describe a few of our latest results – especially DNA knots – along with our initiatives to develop the abilities of sound-condition nanopores even additional, within the direction of single-protein detection, graphene nanopores, plasmonic nanopores, and DNA origami nanopores.